| Friday, November 7 | |
| Class 6 District 1 | |
| (4) Oakville 7 | (1) Jackson 49 |
| (3) Northwest Cedar Hill 14 | (2) Seckman 7 |
| Class 6 District 2 | |
| (4) De Smet 36 | (1) CBC 55 |
| (3) SLUH 25 | (2) Lafayette 28 |
| Class 6 District 3 | |
| (4) Hazelwood West 0 | (1) Pattonville 56 |
| (3) Hazelwood Central 6 | (2) Ritenour 42 |
| Class 6 District 4 | |
| (4) Troy Buchanan 48 | (1) St. Dominic 20 |
| (3) Fort Zumwalt West 16 | (2) Liberty (Wentzville) 7 |
| |
| Class 5 District 1 | |
| (4) Fox 28 | (1) Farmington 49 |
| (3) Webster Groves 14 | (2) Cape Girardeau Central 50 |
| Class 5 District 2 | |
| (4) Rolla 0 | (1) Kirkwood 35 |
| (3) Summit 3 | (2) Eureka 21 |
| Class 5 District 3 | |
| (4) Ladue 21 | (1) Hazelwood East 19 |
| (3) Chaminade 7 | (2) Cardinal Ritter 44 |
| Class 5 District 4 | |
| (4) Timberland 0 | (1) Fort Zumwalt North 45 |
| (3) North Point 21 | (2) Parkway West 50 |
| |
| Class 4 District 1 | |
| (4) Hillsboro 0 | (1) Festus 41 |
| (6) North County 51 | (2) Perryville 7 |
| Class 4 District 2 | |
| (4) Westminster 14 | (1) Vianney 49 |
| (3) Union 21 | (2) Sullivan 28 |
| Class 4 District 3 | |
| (4) Lutheran North 34 | (1) Gateway STEM (Saturday) 0 |
| (3) Jennings 24 | (2) St. Mary’s 40 |
| Class 4 District 4 | |
| (4) Holt 10 | (1) Parkway North 28 |
| (3) University City 12 | (2) Orchard Farm 43 |
| Class 4 District 5 | |
| (4) Mexico 0 | (1) Hannibal 48 |
| (3) Warrenton 3 | (2) Odessa 49 |
| |
| Class 3 District 1 | |
| (4) Scott City/Chaffee 7 | (1) Dexter 42 |
| (3) Potosi 35 | (2) Central (Park Hills) 28 |
| Class 3 District 2 | |
| (4) Herculaneum 8 | (1) Valle Catholic 49 |
| (3) Ste. Genevieve 41 | (2) Lift for Life 54 |
| Class 3 District 3 | |
| (4) Wright City 14 | (1) Borgia 45 |
| (3) St. Charles West 28 | (2) St. Clair 49 |
| Class 3 District 4 | |
| (4) Hallsville 19 | (1) Osage 63 |
| (3) Southern Boone 17 | (2) Moberly 28 |
| Class 3 District 5 | |
| (4) Salem 0 | (1) Mountain Grove 55 |
| (3) St. James 13 | (2) Clever 28 |
| |
| Class 2 District 1 | |
| (5) Central (New Madrid Co.) 0 | (1) Caruthersville 35 |
| (3) St. Vincent 33 | (2) St. Pius X 41 |
| Class 2 District 2 | |
| (4) Hermann 7 | (1) Montgomery County 44 |
| (3) Priory 12 | (2) Bowling Green 54 |
| |
| Class 1 District 3 | |
| (5) Louisiana 48 | (1) Grandview 55 |
| (3) Crystal City 6 | (2) Van-Far 52 |
| |
