Friday
| Kirkwood 66 | Ritenour 22 |
| Lift for Life 0 | De Smet. 20 |
| Hazelwood Central 2 | SLUH 43 |
| Priory 38 | Malden. 24 |
| John Burroughs. 14 | Jennings. 20 |
| Louisville Trinity 52 | CBC 21 |
| Chaminade 41 | Marquette 21 |
| O’Fallon 27 | Francis Howell 26 |
| Borgia 41 | Pacific 14 |
| St. Vincent 14 | De Soto 7 |
| Oakville 14 | Seckman 33 |
| Affton 0 | Herculaneum 42 |
| Parkway South. 49 | Parkway Central. 28 |
| Eureka 49 | Troy Buchanan 48 OT |
| Bayless 14 | Dupo 26 |
| Lutheran North 18 | Cardinal Ritter 30 |
| Wright City 7 | Warrenton 34 |
| Washington 21 | Union 28 |
| MICDS 24 | Ladue 38 |
| University City | Lutheran St. Charles |
| Northwest Cedar Hill 26 | Francis Howell Central 13 |
| Mehlville 23 | Fox 49 |
| Holt 21 | Westminster 37 |
| Fort Zumwalt East | Jacksonville, IL |
| Timberland 21 | Lafayette 28 |
| Edwardsville 7 | Jackson 55 |
| Francis Howell North | Webster Groves |
| Crystal City 12 | Winfield 49 |
| Duchesne 7 | Lutheran South 42 |
| St. Mary’s 14 | IC Catholic 42 |
| West Plains | Miller Career |
| Fort Zumwalt West 14 | Hickman 54 |
| Windsor (Imperial) 34 | Jefferson 20 |
| Liberty (Wentzville) 3 | Cape Central 17 |
| Pattonville 33 | Fort Zumwalt North. 13 |
| North Point 28 | St. Dominic 31 |
| St. Charles West 62 | Clayton 16 |
| Kennett | Hillsboro |
| Summit 38 | Festus 34 |
| McCluer North 43 | St. Charles 6 |
| | |
| Saturday | |
| Hazelwood West | Hazelwood East |
| McCluer | Gateway STEM |
| Principia | Riverview Gardens |
| St. Pius X | Gibson Southern (IN) |
| Thursday | |
| Parkway North 21 | Parkway West 24 |
| Orchard Farm 22 | Fort Zumwalt South. 14 |
| Vianney 35 | Lindbergh 23 |
| Confluence 0 | Normandy 49 |