The jitters of Week 1 are over and the focus of Week 2 begins. Here’s a list of games that will be played around STL this weekend. Check back Friday at 10 p.m. CT as the scoreboard starts to fill in.
Thursday
| Perryville 32 | De Soto 54 |
| Francis Howell 48 | Fort Zumwalt South 20 |
| Hillsboro 28 | Hazelwood East 0 |
| Lindbergh 7 | Oakville 14 |
| Parkway Central 6 | Parkway North 42 |
| Hazelwood West 0 | Pattonville 43 |
| Ladue 50 | Vianney 27 |
| Warrenton 16 | Washinsgton 14 |
| Francis Howell Central 20 | Hazelwood Central 7 |
| Clayton 13 | St. Charles 48 |
| Friday | |
| Festus | St. Mary’s |
| Blair Oaks | Lutheran North |
| Ritenour | Jennings |
| Parkway West | Parkway South |
| Sullivan | Farmington |
| North Point | Seckman |
| Owensville | Borgia |
| Bayless | Grandview |
| University City | Lawton, OK |
| SLUH | CBC |
| Pacific | Orchard Farm |
| De Smet | Cardinal Ritter |
| Lutheran St. Charles | Fort Zumwalt East |
| St. Pius X | Mehlville |
| Louisiana | Winfield |
| Principia | Alton Marquette |
| Fort Zumwalt South | Holt |
| Lafayette | Liberty (Wentzville) |
| MICDS | Richmond |
| Union | Fort Zumwalt West |
| Valle Catholic | Summit |
| Lutheran South | Windsor (Imperial) |
| Herculaneum | Fredericktown |
| Francis Howell North | Timberland |
| Lift for Life | Lenexa (KS) |
| Troy | O’Fallon |
| Kennett | Priory |
| Crystal City | Affton |
| Poplar Bluff | Chaminade |
| Westminster | Wright City |
| St. Dominic | Marquette |
| Hannibal | Eureka |
| Fox | Northwest Cedar Hill |
| Saturday | |
| Duchesne | Veritas Christian |
| Miller Career | Gateway STEM |
| McCluer | McCluer North |
| Normandy | Riverview Gardens |