Conference matchups heat up as the high school football schedule rolls into Week 4. Visit between 10 p.m. and 11 p.m Friday night to watch the scoreboard update in real time.
Arranged alphabetically by home team
| Perryville (1-2) | Bayless (2-1) |
| Liberty North (2-1) | Blue Springs (2-1) |
| Millard South, Neb | Cardinal Ritter (1-2) |
| Crystal City (0-3) | Confluence (0-3) |
| Chaminade (2-1) | De Smet (2-1) |
| De Soto (1-2) | Festus (0-2) |
| Troy 42 | Francis Howell Central 2 |
| Timberland (2-1) | Ft. Zumwalt North (1-2) |
| Francis Howell (1-2) | Ft. Zumwalt West (1-2) |
| Veritas Christian (1-0) | Grandview (0-3) |
| Ritenour (1-2) | Hazelwood East (0-3) |
| Parkway Central 14 | Hazelwood West 57 |
| North County (1-2) | Hillsboro (3-0) |
| St. Mary’s (2-1) | Jackson (3-0) |
| University City (3-0) | Jennings (2-1) |
| Marquette (2-1) | Kirkwood (2-0) |
| Fox (2-1) | Ladue (3-0) |
| Lindbergh (0-3) | Lafayette (2-1) |
| Francis Howell North (0-3) | Liberty (0-3) |
| Wright City (0-3) | Louisiana (3-0) |
| Lift for Life (1-2) | Lutheran St. Charles (0-3) |
| Oakville (2-1) | McCluer North (3-0) |
| Northwest Cedar Hill (2-1) | Mehlville (0-3) |
| Linn (0-3) | Miller Career (0-3) |
| McCluer (0-3) | Normandy (1-2) |
| Ft. Zumwalt East (2-1) | North Point (0-3) |
| Winfield (2-1) | Orchard Farm (2-1) |
| Sullivan (2-1) | Owensville (0-3) |
| Union (2-1) | Pacific (0-3) |
| Hazelwood Central (0-3) | Parkway North (1-2) |
| Webster Groves (2-0) | Parkway South (2-1) |
| Riverview Gardens (2-1) | Parkway West (3-0) |
| Seckman (3-0) | Pattonville (3-0) |
| Lutheran South (1-2) | Priory (1-2) |
| Eureka (2-1) | Summit (2-1) |
| Windsor (2-1) | Saxony Lutheran (1-1) |
| Duchesne (0-2) | Scotland County |
| Holt 49 | St. Charles 6 |
| SLUH (2-1) | St. Dominic (2-1) |
| Rolla (0-3) | Borgia (3-0) |
| St. Clair (2-1) | St. James (2-1) |
| Central – Park Hills (1-2) | St. Pius X – Festus (2-1) |
| Herculaneum (1-2) | St. Vincent (3-0) |
| Gateway (2-0) | Tremont (IL) |
| CBC (2-1) | Vianney (2-1) |
| St. Charles West (3-0) | Warrenton (2-1) |
| Ft. Zumwalt South (0-3) | Washington (0-3) |
| MICDS (2-1) | Westminster (3-0) |