Conference matchups heat up as the high school football schedule rolls into Week 4. Visit between 10 p.m. and 11 p.m Friday night to watch the scoreboard update in real time.
Arranged alphabetically by home team
| Millard South, Neb 55 | Cardinal Ritter 40 |
| Crystal City 44 | Confluence 16 |
| Chaminade 14 | De Smet 62 |
| De Soto 6 | Festus 36 |
| Troy 42 | Francis Howell Central 2 |
| Timberland 21 | Ft. Zumwalt North 20 |
| Francis Howell 31 | Ft. Zumwalt West 7 |
| Veritas Christian 40 | Grandview 22 |
| Ritenour 32 | Hazelwood East 24 |
| Parkway Central 14 | Hazelwood West 57 |
| North County 15 | Hillsboro 45 |
| St. Mary’s 7 | Jackson 42 |
| University City 22 | Jennings 0 |
| Marquette 21 | Kirkwood 52 |
| Fox 14 | Ladue 27 |
| Lindbergh 28 | Lafayette 27 |
| Francis Howell North 0 | Liberty (Wentzville) 63 |
| Wright City 27 | Louisiana 41 |
| Lift for Life 49 | Lutheran St. Charles 0 |
| Oakville (2-1) | McCluer North (3-0) (Sat) |
| Northwest Cedar Hill 35 | Mehlville 6 |
| Linn (0-3) | Miller Career (0-3) (Sat) |
| McCluer 22 | Normandy 8 |
| Ft. Zumwalt East 14 | North Point 42 |
| Winfield 15 | Orchard Farm 48 |
| Sullivan 60 | Owensville 0 |
| Union 56 | Pacific 20 |
| Hazelwood Central (0-3) | Parkway North (1-2) |
| Webster Groves 0 | Parkway South 41 |
| Riverview Gardens 0 | Parkway West 50 |
| Seckman 0 | Pattonville 35 |
| Lutheran South (1-2) | Priory (1-2) (Sat) |
| Eureka 22 | Summit 7 |
| Windsor 20 | Saxony Lutheran 52 |
| Duchesne 0 | Scotland County 56 |
| Holt 49 | St. Charles 6 |
| SLUH 33 | St. Dominic 3 |
| Rolla 47 | Borgia 13 |
| St. Clair 34 | St. James 0 |
| Central – Park Hills 0 | St. Pius X – Festus 54 |
| Herculaneum 7 | St. Vincent 42 |
| Gateway 8 | Tremont (IL) 27 |
| CBC 56 | Vianney 28 |
| St. Charles West 17 | Warrenton 0 |
| Ft. Zumwalt South 28 | Washington 26 (OT) |
| MICDS (2-1) | Westminster (3-0) (Sat) |
| Cuba 0 | Jefferson 27 |
| Perryville 35 | Bayless 14 |