The final third of the regular season kicks off with exciting matchups throughout the St. Louis region. Check in between 10 and 11 p.m. Friday to watch the scoreboard fill in.
*Organized alphabetically by home team
| Lift for Life 22 | Cardinal Ritter 30 (Thu.) |
| Miller Career (1-5) | Cassville (5-1) |
| Chaminade (4-2) | CBC (3-3) |
| Lutheran St. Charles (0-6) | Confluence (0-5) |
| St. Pius X (KC) (5-1) | De Smet (5-1) |
| Hillsboro (5-1) | De Soto (3-3) |
| Crystal City (1-5) | Duchesne (2-4) |
| Hannibal (3-3) | Festus (4-2) |
| Troy (5-1) | Francis Howell (4-2) |
| Fort Zumwalt East (3-3) | Fort Zumwalt North (3-3) |
| Francis Howell North 6 | Fort Zumwalt West 62 (Thu.) |
| Maryville (6-0) | Gateway (3-2) |
| Jefferson (4-2) | Grandview (0-6) |
| Seckman 40 | Hazelwood East 6 (Thu.) |
| Bayless (2-4) | Herculaneum (3-3) |
| Fox (3-3) | Kirkwood (4-1) |
| Eureka (5-1) | Ladue (6-0) |
| Francis Howell Central (3-3) | Liberty (Wentzville) (1-5) |
| Parkway West (5-1) | Lindbergh (2-4) |
| Westminster (4-2) | Lutheran South (1-5) |
| Hazelwood West (2-4) | Marquette (3-3) |
| Affton (3-3) | McCluer North (4-2) (Sat.) |
| Lutheran North (2-3) | MICDS (5-1) (Sat.) |
| Windsor (2-4) | North County (2-4) |
| Washington (1-5) | North Point (1-5) |
| Jennings (2-4) | Northwest Cedar Hill (5-1) |
| Clayton (0-6) | Oakville (5-1) |
| St. Charles (2-4) | Orchard Farm (4-2) |
| St. Clair (5-1) | Owensville (0-6) |
| Lafayette (2-4) | Parkway Central (0-6) |
| Ritenour (4-2) | Parkway North (3-3) |
| McCluer (3-3) | Parkway South (3-3) |
| Hazelwood Central (1-5) | Pattonville (5-1) |
| Potosi (2-4) | Perryville (3-3) |
| John Burroughs (1-3) | Priory (2-4) |
| Riverview Gardens (3-3) | Summit (3-3) |
| Vianney (2-4) | SLUH (4-2) |
| Holt (3-3) | St. Charles West (6-0) |
| St. Dominic (3-3) | St. Francis Borgia (4-2) |
| Union (5-1) | St. James (2-4) |
| Pacific (1-5) | St. Mary’s (4-2) |
| Farmington (5-1) | St. Pius X (Festus) 5-1 |
| Cuba (3-3) | St. Vincent (5-1) |
| Hermann (1-5) | Sullivan (4-2) |
| Fort Zumwalt South (1-5) | Timberland (5-1) |
| Mehlville 0 | University City 13 (Forfeit win) |
| Ste. Genevieve (5-1) | Valle Catholic (6-0) |
| Principia (1-4) | Veritas Christian (3-1) |
| Winfield (3-3) | Warrenton (3-3) |
| Normandy (2-4) | Webster Groves (3-2) |
| Van-Far (1-5) | Wright City (2-4) |