The final third of the regular season kicks off with exciting matchups throughout the St. Louis region. Check in between 10 and 11 p.m. Friday to watch the scoreboard fill in.
*Organized alphabetically by home team
| Lift for Life 22 | Cardinal Ritter 30 (Thu.) |
| Miller Career 0 | Cassville 13 (Forfeit win) |
| Chaminade 35 | CBC 49 |
| Lutheran St. Charles 48 | Confluence 6 |
| St. Pius X (KC) 28 | De Smet 34 |
| Hillsboro 56 | De Soto 13 |
| Crystal City 6 | Duchesne 20 |
| Hannibal 12 | Festus 21 |
| Troy 14 | Francis Howell 10 |
| Fort Zumwalt East 13 | Fort Zumwalt North 49 |
| Francis Howell North 6 | Fort Zumwalt West 62 |
| Maryville 47 | Gateway 8 |
| Jefferson 43 | Grandview 0 |
| Seckman 40 | Hazelwood East 6 |
| Bayless 18 | Herculaneum 46 |
| Fox 21 | Kirkwood 35 |
| Eureka 37 | Ladue 40 (OT) |
| Francis Howell Central 12 | Liberty (Wentzville) 13 |
| Parkway West 7 | Lindbergh 45 |
| Westminster 49 | Lutheran South 0 |
| Hazelwood West 0 | Marquette 58 |
| Affton 12 | McCluer North 56 |
| Lutheran North 55 | MICDS 35 |
| Windsor 14 | North County 48 |
| Washington 40 | North Point 38 |
| Jennings 0 | Northwest Cedar Hill 69 |
| Clayton 0 | Oakville 63 |
| St. Charles 0 | Orchard Farm 35 |
| St. Clair 36 | Owensville 0 |
| Lafayette 47 | Parkway Central 0 |
| Ritenour 16 | Parkway North 14 |
| McCluer 8 | Parkway South 41 |
| Hazelwood Central 0 | Pattonville 67 |
| Potosi 44 | Perryville 21 |
| John Burroughs 34 | Priory 13 |
| Riverview Gardens 14 | Summit 35 |
| Vianney 12 | SLUH 42 |
| Holt 14 | St. Charles West 21 |
| St. Dominic 24 | St. Francis Borgia 0 |
| Union 49 | St. James 6 |
| Pacific 12 | St. Mary’s 58 |
| Farmington 41 | St. Pius X (Festus) 20 |
| Cuba 6 | St. Vincent 49 |
| Hermann 14 | Sullivan 63 |
| Fort Zumwalt South 39 | Timberland 47 |
| Mehlville 0 | University City 13 (Forfeit win) |
| Ste. Genevieve 7 | Valle Catholic 55 |
| Principia 70 | Veritas Christian 35 |
| Winfield 0 | Warrenton 41 |
| Normandy 26 | Webster Groves 11 |
| Van-Far 18 | Wright City 48 |